Quō vādis, Artificial Cancer? Biomechanical characterization of cells cultured on 1D, 2D and in 3D polymer-based scaffolds (Dr. Aldo Leal-Egaña, Heidelberg University)
Apr 15, 2021
Online
Dr. Aldo Leal-Egaña:
Institute of Molecular Systems Engineering (IMSE), Heidelberg University
Abstract:
Cancer progression can be defined by the generation of multiple phenotypes from a single malignant geno-type (i.e. tumor heterogeneity), exhibiting differences in terms viability, proliferation rate, drug sensitivity and expression of biological markers, among others.
Concerning their biomechanical characterization, even though there is an increasing number of scientific publications on the field, there are still unsolved questions regarding the study of is phenomenon in vitro, such as how could be possible to stimulate the apparition of heterogeneous populations, and when.
To achieve these challenges, during the last years our team has been focused on designing, performing and validating several polymer-based scaffolds mimicking the neoplastic milieu. In order to enrich our study, Single-Cell Traction Force Microscopy has been carried out on cells migrating on 1D (i.e. Thin guidelines), pre-cultured on 2D (i.e. Hard culture plates; Soft hydrogels) or preconditioned to 3D (i.e. Polymer-based tumor-like microcapsules; Suspended spheroids).
Furthermore, with the purpose to determine the existence of a progression trend of tumor heterogeneity in vitro, assays have been also done at different time-points, with surprising outcomes.
Among others, our results are clearly showing the apparition of different cell populations in 3D with respect to 2D milieus, exhibiting differences in size, cell-matrix adhesion forces, expression of molecular markers, number of nuclei, and in vivo extravasation capabilities.
These findings are rising new queries in cancer analytics, such as the best strategy to study cell malignancy at lab-scale (1D, 2D or 3D?), as well as when should we sample them to obtain the most reliable experi-mental results.
Biography:
Dr. Leal-Egaña is a Chilean researcher, holding a PhD in Biochemistry from the University of Leipzig. He has been working in different European countries (Germany, France, UK) before obtaining a DGF grant (modality “Eigene Stelle”), to combine his expertise in biomaterials and biophysics, enabling him to study cancer progression in vitro, ex vivo, and in vivo. Among other recognitions, during 2020 his project was selected as “TOP 25 for the Innovation Leben Award” by Bayern Innovativ. Since February 2021, Dr. Leal-Egaña works at the Institute for Molecular Systems Engineering, University of Heidelberg.
Add to your iCal calendar
zurück
“Fluorine in peptide, protein and bacterial cell engineering” (Prof. Dr. Beate Koksch, FU Berlin)
Apr 15, 2021 from 05:00 PM to 06:30 PM
Online
The presentatio is part of the Course of Lectures of the Department of Chemistry, everybody interested is cordially invited. For receiving the link per e-mail, click in the openOLAT menu "Registration".
Prof. Dr. Anna McConnell; Prof. Dr. Thisbe Lindhorst
Add to your iCal calendar
zurück
Uncovering switching and failure mechanism in memristive devices by in-situ spectromicroscopy (Regina Dittmann, Forschungszentrum Juelich GmbH & RWTH Aachen University)
Apr 22, 2021 from 04:00 PM to 05:00 PM
Online
Dr. Regina Dittmann
Peter Gruenberg Institute 7, Forschungszentrum Juelich GmbH & RWTH Aachen University
Abstract
It is generally assumed that voltage-driven oxygen-ion migration and the resulting nanoscale redox processes drive the resistance change in transition metal oxide based memristive devices. Direct observation of the switching and failure mechanism, however, remain challenging because the net changes of structure, stoichiometry, and valence state during switching are very small and occur primarily at electrode interfaces or within nanoscale filaments.
Here we will present local changes in the chemical and electronic structure of SrTiO3-based memristive devices utilizing high-resolution operando characterization tools like transmission electron microscopy (TEM) and photoemission electron microscopy (PEEM). We chose SrTiO3 as a single crystalline model material, which offers a well-understood platform and well-characterized spectroscopic signatures.
To overcome the surface sensitivity typically limiting PEEM investigations of memristive devices, we either delaminated the top electrode in-situ [1] or employed photoelectron-transparent graphene top electrodes were used to attain spectroscopic information from the buried SrTiO3 layer [2]. We could thereby determine the position of in-gap states within the SrTiO3 filaments and use it as input for our calculations of the electronic transport [3]. Quantitative maps of the oxygen vacancy concentration obtained during in situ switching confirm that localized oxygen evolution and reincorporation reactions rather than purely internal movement of oxygen vacancies cause the resistance change. A remarkable agreement between experimental quantification of the redox state and device simulation reveals that changes in oxygen vacancy concentration by a factor of 2 at electrode-oxide interfaces cause a modulation of the effective Schottky barrier and lead to >2 orders of magnitude change in device resistance [2].
Moreover, in-situ PEEM analysis enabled us to identify the microscopic origin of retention failure in SrTiO3 devices [1] and to reveal two different mechanisms for the cycle-to-cycle variability of our devices, namely the change of the shape of the filaments and the movement of filaments during cycling [4].
Download the abstract as pdf-file
Add to your iCal calendar
zurück
Inaugural lecture: "Solid State Chemistry and Catalysis" (Prof. Dr. Malte Behrens)
Apr 22, 2021 from 05:00 PM to 06:30 PM
Online
The presentatio is part of the Course of Lectures of the Department of Chemistry, everybody interested is cordially invited! For receiving the link per e-mail, click in the openOLAT menu "Registration".
Add to your iCal calendar
zurück
Transient atmospheric plasmas – mastering the nonequilibrium (Prof. Dr. Achim von Keudell, Bochum)
Apr 27, 2021 from 04:15 PM
Online
Abstract
Non equilibrium atmospheric plasmas form the unique basis for a multitude of applications ranging from thin films, surface modification, plasma chemistry to plasma medicine. In all these cases atmospheric pressure plasmas exhibit an intimate coupling to the bounding surfaces that trigger surface and conversion processes. The complexity of these processes makes a detailed understanding very challenging. Prominent examples are the combination of plasmas and catalysis and of plasmas and electrolysis. Plasmas provide either excited species to change the conversion reaction paths or they alter and may regenerate catalytic surfaces. The analysis requires detailed diagnostics of plasma excitation and surface processes at the plasma-solid or the plasma-liquid-solid interfaces. Three examples are being presented: (i) the conversion of CO2 and of volatile organic compounds is studied in atmospheric pressure plasmas revealing a strong non equilibrium with respect to excitation temperatures and plasma dynamics; (ii) the conversion of water by plasma excitation using nanosecond high voltage pulses that trigger extremely high density plasmas that are governed by field effects at the interfaces and by tunneling in between adjacent water molecules during plasma propagation; (iii) the plasma induced triggering of enzyme driven species conversion in biocatalysis. The work is supported by the SFB 1316 “Transient atmospheric pressure plasmas – from plasmas to liquids to solids”.
Prof. Benedikt
Add to your iCal calendar
zurück
KiNSIS Colloquium: tba
May 05, 2021 from 12:00 PM to 01:00 PM
Add to your iCal calendar
zurück
Leben auf Exoplaneten? 3. Akt (Prof. Dr. Ruth Schmitz-Streit, Prof. Dr. Wolfgang J. Duschl, Prof. Dr. Ulrich Lüning)
May 06, 2021 from 05:00 PM to 06:30 PM
Online
This presentation can be watched clicking in the BigBlueButton menu item left on the OLAT page (GDCh presentations - WS2020/2021):
https://lms.uni-kiel.de/auth/RepositoryEntry/3674374150/CourseNode/102486011827618
The presentatio is part of the Course of Lectures of the Department of Chemistry, everybody interested is cordially invited!
https://www.chemie.uni-kiel.de/en/course-of-lectures?set_language=en
Add to your iCal calendar
zurück
KiNSIS General Assembly
May 07, 2021 from 02:00 PM to 04:00 PM
Online
More information will follow.
Add to your iCal calendar
zurück
KiNSIS Colloquium: tba
Jun 02, 2021
to
Jun 03, 2021
Add to your iCal calendar
zurück
Jun 09, 2021
to
Jun 11, 2021
Online
This 11th International Conference of the NanoTech Poland will be an online virtual edition, with hybrid (in-person) participation in the conference for local conference participants, organized by the NanoBioMedical Centre in Poznan. The decision has been made due to COVID-19 in order to ensure the safety of the conference community. The conference promises an interesting, also in its diversity, scientific programme, and an international forum for the discussion on the latest scientific achievements and challenges in the field of nanoscience and nanotechnology. The conference will be also a great networking opportunity for exchanging knowledge, scientific ideas between prominent scientists, early-stage researchers, students and scientists from nanotechnology-related companies. Read more
Conference programme:
The Conference programme will feature a strong scientific agenda focused on Nanotechnology in energy, electronics, environment, biomedicine and other relevant fields. An important conference activity will be the Young Researchers Forum, the purpose of which is to recognize early-stage researchers by giving them the opportunity of presenting their recent scientific accomplishments in short oral presentations and during e-poster session.
Important deadlines:
Early registration fee: Payment up to 30 April, 2021
Abstract submission: Up to 30 April, 2021
Abstract acceptance for oral presentations: Up to 9 May, 2021
Conference Website
The NanoBioMedical Centre (NBMC) is an organizational unit of Adam Mickiewicz University in Poznan (AMU) and was established in partnership with Poznan University of Medical Science, Poznan University of Life Sciences and Poznan University of Technology.
Add to your iCal calendar
zurück
KiNSIS Colloquium: tba
Jul 07, 2021 from 12:00 PM to 01:00 PM
Add to your iCal calendar
zurück
Aug 04, 2021
to
Aug 06, 2021
Empire Riverside Hotel, Hamburg, Germany
The NIBS 2021 conference is the fourth annual NIBS conference with the series starting in 2017. NIBS is organized by the Mads Clausen Institute at the University of Southern Denmark, the Kaunas University of Technology, Lithuania and the North German Initiative Nanotechnology Schleswig-Holstein e.V. (NINa SH eV) network, led by Kiel University, Germany. Read more
Attendees from industry, academia and municipalities are invited to enter in a dialogue about the potential for interdisciplinary applications and new products from nanotechnology.
NIBS offers:
- state-of-the-art stimulating presentations
- matchmaking events
- a dialogue platform between experienced and young researchers from industry and academia
NIBS provides presentations from companies and research institutions on current trends in the field of nanotechnology. Companies have the opportunity to communicate their success stories and the newest developments in-house. Young scientists present their work and find entrepreneurial opportunities.
Why NIBS?
In contrast to national conferences, NIBS brings together researchers and business stakeholders from the Baltic Sea Region (BSR) as well as parties involved in the cooperation with the BSR partners to share latest achievements in research, innovative solutions and applications in the field of nanotechnology. NIBS focuses on the BSR, where the innovation potential from newest technologies is utmost high.
The NIBS conference offers an ideal opportunity to increase your visibility as a scientist, company or other stakeholder in the field of nanotechnology within the Baltic Sea region. You can benefit from an active regional nanotechnology network and get a perfect stage to initiate new projects or start-ups and find new partners and customers, respectively.
Topics
- Nanotech for Life Science
- Nano energy
- Nanomaterials
- Nanooptics
- Nanoelectronics
- Sensors
- Sustainable Nanotechnology
Important dates:
- Deadline for abstract submission: 01 June 2021
- Registration deadline: 01 June 2021
- Early bird deadline: 01 April 2021
https://nibs.nina-sh.de/
Add to your iCal calendar
zurück
